Jsc pharmaceutical plant Aegis Hungary. Activities of the company “egis

Means that inhibit the formation of urinary calculi and excrete them with urine.

Composition

The active substance is allopurinol.

Manufacturers

Egis Pharmaceutical Plant (Hungary)

pharmachologic effect

Hypuricemia, anti-gout.

It inhibits xanthine oxidase, disrupts the conversion of hypoxanthine to xanthine and xanthine to uric acid.

Almost completely absorbed from the digestive tract.

The maximum concentration is reached after 1.5 hours.

The elimination half-life is 1-2 hours.

It is excreted by the kidneys and through the intestines.

Side effect

Reversible angioimmunoblastic lymphadenopathy and granulomatous hepatitis, thrombocytopenia, agranulocytosis, aplastic anemia, general malaise, asthenia, headache, nausea, vomiting, taste disorder, stomatitis, fever, vertigo, ataxia, drowsiness, paralysis, coma, coma vision, cataract, angina pectoris, bradycardia, hypertension, edema, alopecia, furunculosis, hyperglycemia, hyperlipidemia, hematuria, uremia, gynecomastia, infertility, impotence, skin allergic reactions, angioedema nuts.

Indications for use

Hyperuricemia:

  • primary and secondary gout, urolithiasis with the formation of uric acid stones, diseases accompanied by increased decay of nucleoproteins, cytostatic and radiation therapy of tumors, psoriasis, traumatic toxicosis, corticosteroid therapy to prevent urate nephropathy;
  • malignant neoplasms and congenital disorders of purine metabolism in children.

Contraindications

Hypersensitivity, severe renal failure, pregnancy and lactation.

Dosage and administration

Inside, after a meal.

Start with 100 mg / day, once, then the dose is gradually increased.

If side effects from the gastrointestinal tract occur at a dose of 300 mg per day, fractional administration is possible.

  Adults:

  • 100-200 mg per day,
  • with a state of moderate severity - 300-600 mg per day,
  • in serious condition - 700-900 mg per day.

  For children:

  • up to 15 years - 10-20 mg / kg per day (maximum up to 400 mg per day).

With severe renal failure - 100 mg per day or 100 mg with an interval of more than 1 day.

Overdose

Symptoms

  • dizziness
  • nausea
  • vomiting
  • diar
  • oliguria.

  Treatment:

  • forced diure,
  • hemo-and peritoneal dialysis.

Interaction

Increases blood concentration and toxicity of azathioprine, mercaptopurine, methotrexate, xanthines (theophylline, aminophylline), hypoglycemic effect of chlorpropamide, anticoagulant - indirect anticoagulants.

Pyrazinamide, salicylates, uricosuric agents, thiazide diuretics, furosemide, ethacrylic acid weaken the hypuricemic effect.

Against the background of amoxicillin, ampicillin, bacampicillin, the likelihood of a skin rash increases.

special instructions

Diuresis should be maintained at least 2 liters per day and a neutral or slightly alkaline urine reaction.

It is not recommended to start therapy until the complete relief of an acute attack of gout; during the first month of treatment, preventive use of NSAIDs or colchicine is necessary; in the case of an acute attack of gout during treatment, anti-inflammatory drugs are additionally taken.

In case of impaired renal and hepatic function, the dose should be reduced.

The use of azathioprine or 6-mercaptopurine on the background of allopurinol allows a 4-fold reduction in their doses.

Combined with caution with vidarabine.

The activities of the company "EGIS"   covers all parts of the pharmaceutical supply chain: from research and development, production of active pharmaceutical ingredients and finished products to sales and marketing. The company's capabilities cover all stages of research and development of medicines, production and sales, allowing you to fully control the quality of products over the expiration date and be more sensitive to changes in market conditions. Currently, the product range includes 531 drugs (of various forms and dosages), which belong to 137 groups of drugs and contain 119 types of active ingredients.

In 2013 CJSC Pharmaceutical Plant EGIS celebrated its centenary since its founding. During these 100 years, the company not only successfully coped with difficulties and competition, but also became one of the leading pharmaceutical companies in Central and Eastern Europe, thanks to activities that span the entire pharmaceutical production cycle, high-quality drugs and outstanding research and development potential. All these years have been characterized by continuous renewal and development, but one thing remains unchanged: EGIS serves to protect health, life and quality. CJSC Pharmaceutical Plant EGIS (Hungary) is a vertically integrated company, its activities cover all areas of the value chain in the pharmaceutical industry: from research and development, production of active pharmaceutical ingredients and finished products to sales and marketing. The history of the company dates back more than a century, and during these one hundred years EGIS company not only successfully coped with the competition, but also became one of the leading pharmaceutical companies in Central and Eastern Europe.

EGIS activities in the field of scientific research   and development has been going on for eight decades. Every year 9% of sales is spent - this is more than 40 million euros - for research and development, becoming one of the most actively investing in research and development among all industrial enterprises in Central and Eastern Europe.

According to the results of the 2011/2012 financial year, 2822 registration certificates were received, of which 2501 were abroad and 321 in Hungary. The excellent results in the field of drug development at EGIS have been recognized and awarded with 7 prestigious awards for introducing innovations over the past two decades.

Due to the rapid expansion of the international market in recent decades, the company "EGIS" has opened representative offices in 18 countries, the company's products are sold in almost 60 countries. 76% of the EUR 452 million of the total net sales revenue is exported. Today, the total staff of EGIS, including foreign representative offices, is 4,000 people, the company takes 28th place in the ranking of the largest employers in Hungary.

EGIS Pharmaceutical Plant CJSC (Hungary) is a vertically integrated company, a leading regional manufacturer of high-quality generics and products with high added value. We are an internationally recognized company that uses advanced research technologies and highly innovative approaches in the field of drug development in its work.

Strategic goal
the company    We manufacture our products in order to provide modern treatment and contribute to improving the quality of life of patients and their duration.

Our mission    Health is the most important and precious treasure of man. More than a hundred years ago, we devoted ourselves to the desire to preserve this treasure.    Combining our knowledge, we serve people to make their life long and healthy.


FROM MOLECULES TO THE WORLD MARKET

The company's activities cover all parts of the pharmaceutical supply chain: from research and development, production of active pharmaceutical ingredients and finished products to sales and marketing.

Research and development

The success and effectiveness of new drugs is very important for the future of the EGIS company, therefore one of the main priorities of the company’s activities is the constant work on their development. Mainly, EGIS is engaged in the development of generic drugs, but also conducts research work aimed at developing new original drugs.
EGIS annually spends a substantial amount on research and development - 10% of sales - this is about 43 million euros.

Production

The company "EGIS" produces medicines at three modern production sites located in Hungary. Our manufacturing system complies with the International Pharmaceutical Manufacturing and Control Rules (GMP, Good Manufacturing Practice), as well as the regulations of the Hungarian National Pharmaceutical Institute (OGYI) and the United States Food and Drug Administration (FDA).

Sales and Marketing

Thanks to the rapid expansion of the international market in recent decades, EGIS has opened representative offices in 18 countries, including Russia. The company's products are sold in 61 countries. Today, the general staff of EGIS, including foreign representative offices, is 4,500 employees.


OUR CORPORATE VALUES:

Having traditions that are more than 100 years old, the EGIS company, from a small family business, has turned into a large international company, which for the past 20 years has been an important and recognized member of the SERVIE group. Many things unite us: a rich history rooted in the family business, and common values.

INNOVATION    The world does not stand still. This is especially true for the pharmaceutical industry, which is constantly facing new challenges. We know this world well, because we are moving with it. We are changing with him. We believe that the key to success is continuous investment and continuous development. Everyone here can be an innovator.

RESPONSIBILITY    There are many of us and we are all different, but we are striving to achieve a common goal by all means. Each of us is aware that the key to the success of the company is in the hands of each of us.

HIGH STANDARDS    Our products are manufactured in accordance with strict rules and meet high quality standards. To do this, we find the best professionals in their fields in all parts of the world.

CUSTOMER ORIENTATION    We strive to ensure that each patient receives the most suitable drug and in the most optimal form. To achieve this, we strictly control the quality of our products throughout the cycle: we ourselves develop, manufacture and supply products to the world market. This is why our drugs are truly reliable.

INTERACTION    Thanks to our products, we make life easier for millions of people around the world. This requires impeccable teamwork, where each employee knows what his role is in this extraordinary process.

ABOUT HUMAN RESOURCES POLICY

The main goal of the personnel policy of EGIS:    To create such an atmosphere in the company that everyone, without exception, an employee receives job satisfaction, feels part of a single team and a common result. It is especially important that new employees can quickly and easily join the team. Indeed, in the future, the success of the company will depend on the teamwork of specialists in various fields. By training staff and providing it with opportunities to realize their potential, we get high-level professionals who effectively cope with the tasks and help us to maintain leading positions at the regional level.

The main objectives of personnel policy:

  • Search and selection of personnel;
  • Assessment of the efficiency and effectiveness of employees;
  • Training and development of employees;
  • Ensuring occupational safety, health and the environment.


WE OFFER

Work in a large international company with a high level of quality and reliability, a friendly atmosphere, ambitious tasks, professional growth, wide opportunities for a successful career.

GOOD WORK AND PAYMENT

We consider the main strategic asset of the company to be the specialists working in it - real professionals, people who are passionate about their business. That is why we make sure that employees have better working conditions, a competitive salary and a bonus system, a substantial social package that provides for medical and life insurance, and extra sickness pay in excess of state payments. We also provide modern means of communication with reimbursement of expenses for telephony and the Internet.

PROFESSIONAL AND CAREER GROWTH

For EGIS employees, perspective, diversity and opportunities are important in their work. To achieve this, we use an effective training system so that everyone has the opportunity for continuous development and new knowledge. We provide opportunities not only for classic career growth, but also for horizontal professional development.

The main value of our company is human relations based on trust, respect and mutual assistance. We spend a significant part of our lives at work. We are a company for which it is important that the atmosphere in which employees work is pleasant and inspiring.

AMBITIOUS TASKS

The company "EGIS" is very fond of ambitious tasks. And for this we need ambitious people - professionals who are ready together with us to achieve more and more heights.


We are looking

Those who are not afraid to dream boldly, vividly, making their dreams a reality.

Those who need to bring joy and satisfaction from their work, develop professionally, set worthy goals and achieve them.

 

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